Postoperatif Deliryumda Dislipideminin Rolü
Araştırma Makalesi
DOI:
https://doi.org/10.5281/zenodo.7977521Anahtar Kelimeler:
Postoperatif Deliryum, Trigiliserid, Düşük Yoğunluklu LipoproteinÖzet
Giriş: Postoperatif deliryum (POD), sıklıkla yaşlı yetişkinlerde görülen, bilişsel işlevlerde ve dikkatte akut bir düşüşle karakterize bir durumdur.
Amaç: Bu çalışmanın amacı preoperatif lipid düzeyleri ile postoperatif deliryum gelişimi arasındaki ilişkiyi araştırmaktır.
Yöntem: : Bu retrospektif çalışmaya, hastanemizde diz ve kalça operasyonları sonrası deliryum gelişen 41 hasta dahil edildi. Deliryum tanısı psikiyatrisler tarafından ‘Konfüzyon Değerlendirme Ölçeği’ anketi kullanılarak konuldu. Hastaların demografik özellikleri, komorbiditeleri, kan biyokimya ve lipid düzeyleri araştırıldı..
Bulgular: POD gelişen hastaların yaş ortalaması 68,63±7,59 ve %61’ i kadındı. Postoperatif deliryum gelişen hastaların total kolesterol (TK), trigliserid (TG), düşük yoğunluklu lipoprotein (LDL), non-yüksek yoğunluklu lipoprotein (HDL) düzeyleri ve TG/HDL, LDL/HDL oranları kontrol grubundan anlamlı derecede yüksek saptandı (p<0,05). C-Reaktif Protein (CRP) ve ferritin düzeyleri postoperatif deliryum gelişen grubta kontrol grubundan istatistiksel olarak anlamlı derecede daha fazla bulundu (p<0,001, p= 0,003).
Sonuç: Sonuçta POD gelişen hastalarda preoperatif TK, TG, LDL ve non-HDL seviyelerini ve lipitle ilgili yeni biyobelirteçler olan TG/HDL, LDL/HDL oranlarını kontrol grubundan anlamlı derecede yüksek bulduk. Hastalarda postoperatif deliryum riski değerlendirilmesinde lipid düzeyleri göz önünde bulundurulmalı, gerekli önlemler alınarak prognozun iyileştirilmesi sağlanmalıdır.
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