Effect of Cardiopulmonary Bypass on C-Reactive Protein

Research Article

Abstract

Introduction: Cardiac surgical operations performed with CPB are mostly operations that have no alternative today. Cardiac surgery operations performed with CPB can activate a systemic inflammatory response.

Objective: In this study, it was aimed to investigate the change in early postoperative CRP level in cardiac surgery operations performed with CPB.

Method: A total of 30 patients who underwent CPB-guided isolated coronary artery bypass graft replacement were included in the study retrospectively after the exclusion criteria (systemic inflammatory disease). In the study, CRP levels were grouped as preoperative and postoperative and compared. The data were evaluated statistically.

Results: The mean age of the patients included in the study was 60.93±9.93 years, their average height was 164.57±11.32 cm, their mean weight was 77.96±14.45 kg, and their mean body surface area was 1.86±0.19 m2. , mean flow values 4.36±0.61 ml/min/m2, mean ejection fraction percentages 51.43±9.40, mean aortic cross clamp times 52.43±22.72 minutes, mean total perfusion times 95.86 It was found to be ±42.76 minutes. The preoperative CRP levels of the patients included in the study were 4.27±0.73, the CRP levels on the postoperative 1st day were 9.77±0.59, and the postoperative CRP levels were higher than the preoperative CRP levels and there was a statistically significant difference (p<0 .05).

Conclusion: We found that CRP level increased significantly on the 1st postoperative day in cardiac surgery operations performed with CPB. We think that the increase in postoperative CRP level in cardiac surgery operations performed with CPB may be a predictor for complications. It is also seen that CPB causes an increase in the CRP level.