2. The Relationship Between Coronary Artery Disease and Platelet Distribution Width (PDW) in Cardiopulmonary Bypass Patients
Research Article
DOI:
https://doi.org/10.5281/zenodo.8060001Keywords:
Coronary Artery Disease, CAD, Platelet Distribution Width, PDWAbstract
Introduction: Coronary artery diseases (CAD) are important cardiovascular diseases and are among the important causes of death.
Objective: This study aimed to investigate the relationship between HR and platelet distribution width (PDW) in cardiopulmonary bypass (CPB) errors.
Method: In this study; A total of 30 patients, 15 men and 15 women, who were diagnosed with CAD and decided to undergo CPB (Patient group), and a total of 30 healthy volunteers, 15 men and 15 women without any cardiac disease (Control group), were included. In this way, a patient and control group with similar demographic characteristics was created. PDW was studied from hemogram blood taken from both groups and evaluated statistically.
Results: The groups; their gender, age, height, weight and body surface area were similar (p>0.05). When the PDW levels of the groups were compared, it was higher in group 1 and there was a statistically significant difference between the two groups (p<0.05).
Conclusion: We think that it may be an important determinant of CAD in PDW. We also think that there may be a relationship between CAD and PDW.
References
Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-16823. doi:10.1002/jcp.28350
Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111(25):3481-3488. doi:10.1161/CIRCULATIONAHA.105.537878
Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017;18(6):331-344. doi:10.1038/nrg.2016.160
Sincer I, Mansiroglu AK, Erdal E, Cosgun M, Aktas G, Gunes Y. Could platelet distribution width predict coronary collateral development in stable coronary artery disease?. North Clin Istanb. 2020;7(2):112-117. Published 2020 Mar 19. doi:10.14744/nci.2019.47374
Yu J, Wang L, Peng Y, et al. Dynamic Monitoring of Erythrocyte Distribution Width (RDW) and Platelet Distribution Width (PDW) in Treatment of Acute Myocardial Infarction. Med Sci Monit. 2017;23:5899-5906. Published 2017 Dec 13. doi:10.12659/msm.904916
De Luca G, Venegoni L, Iorio S, et al. Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets. 2010;21(7):508-514. doi:10.3109/09537104.2010.494743
Bekler A, Ozkan MT, Tenekecioglu E, et al. Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome. Angiology. 2015;66(7):638-643. doi:10.1177/0003319714545779
Hu CP, Du Y, Zhu Y, Shi C, Qin Z, Zhao YX. Platelet Distribution Width on Admission Predicts In-Stent Restenosis in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Treated with Percutaneous Coronary Intervention. Chin Med J (Engl). 2018;131(7):757-763. doi:10.4103/0366-6999.228247
Ege MR, Guray U, Guray Y, Acıkgoz S, Demirkan B. Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. Herz. 2013;38(2):197-201. doi:10.1007/s00059-012-3668-z
Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis [published correction appears in Int J Cardiol. 2014 Dec 20;177(3):1145. AmmarinThakkinstian [corrected to Thakkinstian, Ammarin]]. Int J Cardiol. 2014;175(3):433-440. doi:10.1016/j.ijcard.2014.06.028
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Acta Medica Ruha
This work is licensed under a Creative Commons Attribution 4.0 International License.