The Effect Of Medical Treatment Of Primary Open-Angle Glaucoma On Peripapillary Hemodynamics
Research Article
DOI:
https://doi.org/10.5281/zenodo.8011185Keywords:
primary open angle glaucoma, intraocular pressure, beta blocker, carbonic anhydrase inhibitor, optic nerveAbstract
Objective: Drugs that increase the perfusion of the optic nerve head that is primarily damaged during glaucoma and additionally decrease the intraocular pressure have the potential to improve the prognosis of progressive optic neuropathy by increasing the perfusion of the optic nerve head. In this study, it was aimed to evaluate the effects of 2 topical anti-glaucoma agents on KPSA (short posterior ciliary artery) and SRA (central retinal artery) in patients with high tension primary open-angle glaucoma (POAG).
Method: In a total of 14 hypertensive glaucoma patients, standard doses of timolol, a beta-blocker, and topical carbonic anhydrase inhibitor dorzolamide (2 times a day in each eye) were administered to the short posterior ciliary artery, central retinal artery, choroidal hemodynamics, intraocular pressure. and its effects on systemic perfusion parameters were investigated. Measurements were made before timolol was administered to one eye, 4 weeks later, and four weeks after initiation of combined therapy.
Results: Following administration of timolol in patients with primary open-angle glaucoma, intraocular pressure decreased significantly by 21.4% (from 25.2±1.5 mmHg to 19.8±1.8 mmHg) (p<0.0001). In the group that received timolol and dorzolamide combined treatment, the decrease in intraocular pressure was higher (from 25.2±1.5 mmHg to 16.9±1.9 mmHg) (p<0.0005).
Conclusion: Based on the results of the study, it was concluded that vasoactive drugs have a positive effect on the treatment and prognosis of primary open-angle glaucoma.
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