Metabolik Sendromlu Hastalarda Tam Kan Sayımı Parametreleri, Nötrofil Lenfosit Oranı Ve Trombosit Lenfosit Oranının Araştırılması
Araştırma Makalesi
DOI:
https://doi.org/10.5281/zenodo.8250868Anahtar Kelimeler:
Metabolik Sendrom,, Nötrofil Lenfosit Oranı, , Platelet Lenfosit Oranı.Özet
Giriş: Metabolik sendrom insülin direnci ile başlayan ve sistemik bozuklukların eşlik ettiği ölümcül bir endokrinopatidir. Nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR), lökosit sayısına alternatif olarak inflamasyonda belirleyici olabilir.
Amaç: Bu çalışmada endotel disfonksiyonu, subklinik inflamasyon, pıhtılaşma artışı ve sistemik inflamasyon göstergesi ile karakterize metabolik sendrom; nötrofil-lenfosit oranı (NLR) ile trombosit-lenfosit oranı (PLR) arasındaki ilişkinin gösterilmesi amaçlanmaktadır.
Yöntem: Çalışma, Gaziantep Özel Emek Hastanesi Dahiliye Polikliniğine 01/10/2022 - 30/12/2022 tarihleri arasında genel sağlık kontrolü veya Tip 2 DM takibi için başvuran hastaların demografik bilgileri ve laboratuvar kayıtları retrospektif olarak incelenerek yapılmıştır. Olgular metabolik sendrom ve kontrol grubu olarak 2 gruba ayrıldı. Çalışmaya 63 metabolik sendromlu hasta ve 53 sağlıklı (kontrol grubu) hasta dahil edildi.
Bulgular: Metabolik sendrom grubunda (n=63) nötrofil-lenfosit oranı (NLO) 3,44 (2,87-4,1), kontrol grubunda (n=53) NLO 1,81 (1,65-2,04) ve istatistiksel olarak anlamlı bir farktı (p<0.001). Trombosit-lenfosit oranı (PLR) metabolik sendrom grubunda 198 (169,5-228,5), kontrol grubunda 101 (87,7-114,2) olup istatistiksel olarak anlamlıydı (p<0,001).
Sonuç: Düşük dereceli kronik inflamasyonun nedeni olan metabolik sendrom ile inflamasyonun kolay ve ucuz ulaşılabilir göstergeleri olan NLR ve PLR düzeyleri karşılaştırılmış ve metabolik sendromda NLR ve PLR düzeylerinin anlamlı olarak yüksek olduğu saptanmıştır. Bu sonuç bize bu iki inflamasyon parametresinin kronik hastalıklarda prognostik göstergeler olarak kullanılabileceğini göstermektedir.
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