Investigation Of Full Blood Count Parameters, Neutrophıl Lymphocyte Ratio And Platelet Lymphocyte Ratio In Patients With Metabolic Syndrome
Research Article
DOI:
https://doi.org/10.5281/zenodo.8250868Keywords:
Metabolic Syndrome,, Neutrophil Lymphocyte Ratio, , Platelet Lymphocyte Ratio.Abstract
Introduction: Metabolic syndrome is a fatal endocrinopathy that starts with insulin resistance and is accompanied by systemic disorders. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can be a determinant in inflammation as an alternative to white blood cell count.
Aim: In this study, metabolic syndrome characterized by endothelial dysfunction, subclinical inflammation and hypercoagulability and systemic inflammation indicator; It is aimed to show the relationship between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR).
Method: The study was carried out by retrospectively examining the demographic information and laboratory records of the patients who applied to Gaziantep Private Emek Hospital Internal Medicine Polyclinic between 01/10/2022 - 30/12/2022 for general health control or Type 2 DM follow-up. The cases were divided into 2 groups as metabolic syndrome and control group. 63 patients with metabolic syndrome and 53 healthy (control group) patients were included in the study.
Results: The neutrophil-lymphocyte ratio (NLR) was 3.44 (2.87-4.1) in the metabolic syndrome group (n=63), and the NLR was 1.81 (1.65-2.04) in the control group (n=53), and there was a statistically significant difference (p<0.001). The platelet-lymphocyte ratio (PLR) was 198 (169.5-228.5) in the metabolic syndrome group and 101 (87.7-114.2) in the control group and was statistically significant (p<0.001).
Conclusion: Metabolic syndrome, which is the cause of low-grade chronic inflammation, and NLR and PLR levels, which are easily and inexpensively accessible indicators of inflammation, were compared, and NLR and PLR levels were found to be significantly higher in the metabolic syndrome group. This result shows us that these two inflammation parameters can be used as prognostic indicators in chronic diseases.
References
Reaven G.M. Themetabolicsyndrome: is thisdiagnosisnecessary? Am J ClinNutr. 2006;83, 1237–1247.
Sevket Balta, MD1, Turgay Celik, MD2, Dimitri P. Mikhailidis. The Relation Between Atherosclerosis and the Neutrophil–Lymphocyte Ratio. Clinicaland Applied Thrombosis / Hemostasis. 2016;22(5):405-411.
Laura Fusar-Poli, AntimoNatale, AndreaAmerio. Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder. Brain Sci. 2021;11:58.
Rawan Mohammad Al Saudi, VioletKasabri, Randa Naffa. Glycated LDL-C andglycated HDL-C in association with adiposity, blood and atherogenicityindices in metabolic syndrome patients with and without prediabetes. Ther Adv Endocrinol Metab. 2018;9(10):311-323.
Rimini M, Casadei-Gardini A, Ravaioli A, Rovesti G. Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study. J Clin Med. 2020;9(4):1177.
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-97.
Zaki M, El-Bassyouni HT, Youness ER, et al. Effect of obesity on serum IL-10 concentrations and messenger RNA expression in women with metabolic syndrome. New Zealand Journal of Medical Laboratory Science. 2022;69.
Malik MS, Malik M, Sukhera AB, et al. Metabolic syndrome and related inflammation, prevalence, and predictive value of c-reactive protein in south Asian youths. Metabolic Syndrome and Related Disorders. 2021;19(9):483-490.
Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratislavskelekarskelisty. 2001;102(1):5-14.
-Balta S, Kurtoglu E, Kucuk U, Demirkol S, Ozturk C. Neutrophil–lymphocyteratio as an important assessment tool. ExpertRevCardiovascTher. 2014;12(5):537–538.
Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine. 2012;5(1):2.
Demirtas L, Degirmenci H, Akbas EM, et al. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8(7):11420–11427.
Surendar J, Indulekha K, Mohan V, et al. Association of neutrophil-lymphocyte ratio with metabolic syndrome and its components in Asian Indians (CURES-143). J Diabetes Complic. 2016;30:1525–1529.
Ryu SY, Kim KS, Park J, Kang MG, Han MA. The association between circulating inflammatory markers and metabolic syndrome in Korean rural adults. J Prev Med Public Health. 2008;4:413-418.
Srikanthan K, Feyh A, Visweshwar H, et al. Systematic review of metabolic syndrome biomarkers: a panel forearly detection, management, and risk stratification in thewest Virginian population. Int J Med Sci. 2016;13:25–38.
Ganesh Jialal , Beverley Adams-Huet , Ishwarlal Jialal . Both the platelet count and the platelet: lymphocyte ratio are not increased in nascent metabolic syndrome. Platelets. 2019;30(8):1057-1058.
Varol E, Bas HA, Aksoy F, Ari H, Ozaydin M. Relationship between neutrophil–lymphocyte ratio and isolated low high-density lipoprotein cholesterol. Angiology. 2013;65(7):630–633.
Shasha Y, Xiao fan G, Guang XL. Lymphocyte to High-Density Lipoprotein Ratio but Not Plateletto Lymphocyte Ratio Effectively Predicts Metabolic Syndrome Among Subjects From Rural China. Front Cardiovasc Med. 2021;8:583320.
Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab. 2009;94(9):3171–3182.
-American Diabetes Association (ADA) Standards of MedicalCare in Diabetes--2014. Diabetes Care. 2014;37(Suppl 1):S14–S80.
Atak B, Aktaş G, Duman TT. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Rev Assoc Med Bras. 2019;65(1):38-42.
Sefil F, Ulutas KT, Dokuyucu R, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus. J Int Med Res. 2014;42(2):581–588.
Yılmaz H, Ucan B, Saykı M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9:299-304.
Twig G, Afek A, Shamiss A, et al. White bloodcell countand the risk for coronary artery disease in young adults. PLoS ONE. 2012;7:e47183.
Talukdar S, Oh da Y, Bandyopadhyay G, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secretedelastase. Nat Med. 2012;18:1407-1412.
Fadını GP, Marcuzzo G, Marescottı MC, De Kreutzenberg SV, Avogaro A. Elevated white bloodcell count is associated with prevalence and development of the metabolic syndrome and its components in the general population. Acta Diabetol. 2012;49:445-451.
Furuncuoğlu Y, Tulgar S, Doğan AN, Çakar S, Tulgar YK, Çakıroğlu B. Obezitenin nötrofil/lenfosit ve trombosit/lenfosit oranını, sistemik immün-inflamatuar indeksi ve trombosit indekslerini nasıl etkilediği: retrospektif bir çalışma. Eur Rev Med Pharmacol Sci . 2016;20(7):1300-1306.
Brun JF, Aloulou I, Varlet-Marie E. Hemorheological aspects of the metabolic syndrome: markers of insulin resistance, obesity or hyperinsulinemia? Clin Hemorheol Microcirc. 2004;30:203-209.
Zhao F, Yan Z, Meng Z, et al. Relationship between mean platelet volume and metabolic syndrome in Chinese patients. Sci Rep. 2018;8(1):14574.
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