Monoclonal Gammopathy with Isolated CA 19-9 Elevation: A Rare Case
Case Report
DOI:
https://doi.org/10.5281/zenodo.17166520Keywords:
Monoclonal Gammopathy, CA 19-9, Diagnostic Difficulty, Tumor MarkerAbstract
Objective: CA 19-9 is a tumor marker used in the diagnosis of pancreatic and gastrointestinal cancers, but its isolated elevation can also be seen in benign conditions.
Method and Result: A 48-year-old man presented with complaints of abdominal pain and malaise and a CA 19-9 level of 500 U/mL. Imaging studies did not show malignancy. Serum protein electrophoresis revealed IgG class monoclonal protein and bone marrow biopsy was normal. The patient was diagnosed with monoclonal gammopathy of unknown significance. Six months later, CA 19-9 level decreased to 300 U/mL and no malignancy developed.
Conclusion: Isolated CA 19-9 elevation may be associated with causes other than malignancy and may be related to monoclonal gammopathy. In such cases, careful evaluation and unnecessary procedures should be avoided.
References
Klein A, Zheng M, Wang J, et al. Clinical significance of CA 19-9 in pancreatic cancer. J Clin Oncol. 2020;38(8):962-971.
Kauffmann J, Greenberg R, Ritter G, et al. CA 19-9 in diagnosis and prognosis of gastrointestinal malignancies. Eur J Cancer. 2018;94:83-91.
Rajkumar SV. Multiple myeloma: Current treatment algorithms. Oncologist. 2016;21(10):1188-1198.
Liu X, Wang J, Li W, et al. The clinical significance of CA 19-9 in various malignancies. Clin Cancer Res. 2021;27(12):3501-3510.
Watanabe M, Yamada T, Kawai K, et al. Utility of CA 19-9 in the diagnosis and prognosis of gastrointestinal malignancies. J Gastroenterol. 2019;54(5):417-426.
Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2008;358(26):2694-2705.
Durie BGM, Kyle RA. Myeloma: Current treatment algorithms. Blood. 2006;108(3):950-960.
Zhang Y, Liu T, Qiu H, et al. Correlation between CA 19-9 levels and clinical features in patients with monoclonal gammopathy. Hematology. 2019;24(1):1-6.
Landgren O, Kyle RA, Pfeiffer RM, et al. Monoclonal gammopathy of undetermined significance: An update. Cancer. 2013;119(17):3149-3156.
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