The Prognostic Role of Biomarkers in Pulmonary Contusion
Research Article
DOI:
https://doi.org/10.5281/zenodo.10823226Keywords:
Pulmonary Contusion, Biomarker, PrognosisAbstract
Objective: Within the scope of this research, we aimed to elucidate the treatment and follow-up of pulmonary contusion patients by revealing the prognostic role of biomarkers. All parameters in total blood samples taken from the cases at the first admission were analyzed as biochemical biomarkers.
Method: A total of 482 patients aged 18 and over admitted to our institution due to thoracic traumas were examined. Among the cases admitted to the emergency department with injuries accompanied by blunt thoracic trauma, cases with radiologically proven pulmonary contusion were included in the study.
Results: WBCs, neutrophil, and lymphocyte count, neutrophil-lymphocyte ratio (NLR), ALT, AST, and LDH values were significantly higher in the group with pulmonary contusion (p<0.05). The lymphocyte levels were significantly lower in pulmonary contusion patients (p<0.05). The rate of complications, intensive care unit stay, requirement for mechanical ventilation, and mortality rate were significantly higher in the group with pulmonary contusion (p>0.05). The univariate analysis found that WBC, neutrophil and lymphocyte count, NLR, ALT, AST, and LDH parameters denoted a statistically significant difference between the two groups (p>0.05). WBC, neutrophil count, NLR, ALT, AST, and LDH values were significantly elevated in the group with lung contusion>50% (p<0.05).
Conclusion: In this study, WBC, neutrophil and lymphocyte count, NLR, ALT, AST, and LDH were predictive biomarkers. Additionally, age, motor vehicle accidents, falls, impact trauma mechanism, pneumothorax, injury site, and number of rib fractures were other contributing predictors that allow a wider range of clinical application and decision-making.
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