Comparison of Ykl-40 In Patients With & Without Gestational Diabetes Mellitus In The First Trimester & At Weeks 24 – 28

Research Article


  • Neslihan Erkal Antalya eğitim ve araştırma hastanesi



Gestational diabetes mellitus,, HOMA-IR ,, YKL-40.


Objective: To elucidate whether the YKL-40 level in the first trimester is effective in predicting the development of diabetes in pregnant groups with and without gestational diabetes mellitus.

Methods: All first-trimester pregnant cases between the ages of 18 – 35 years who applied to the obstetrics and gynecology outpatient clinic of Antalya Training and Research Hospital with a single pregnancy, who did not have additional diseases and fetal anomalies, were included in the study (n=250). An oral glucose tolerance test of 75 gr (OGTT) was performed weekly to diagnose GDM in all pregnant women 24 – 28. During the administration of OGTT, fasting venous blood was taken to check the level of YKL-40.

Results: A total of 250 patients have been enrolled within the scope of this study. According to the results of OGTT, 18 individuals were diagnosed with GDM. Notably, while there was a difference in YKL-40 measurements in all patients, buts no difference in sub-group analysis. The differences between the first YKL-40, second YKL-40, and YKL-40 difference values of patients with and without GDM were evaluated. There was no statistically significant difference between the first, second, and YKL-40 difference values of patients with and without GDM (p>0.05).

Conclusion: Regarding the results of this research, YKL-40 might be valuable in detecting low-grade inflammation in pregnant women. However, there is a need for larger-scale prospective randomized studies from the early period to the end of pregnancy to better and more accurately evaluate the relationship between insulin resistance and inflammation.


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How to Cite

Erkal, N. (2023). Comparison of Ykl-40 In Patients With & Without Gestational Diabetes Mellitus In The First Trimester & At Weeks 24 – 28: Research Article. Acta Medica Ruha, 1(3), 202–209.



Research Articles