4. Comparison of Troponin-I Levels Before and After Cardiopulmonary Bypass in Diabetic and Nondiabetic Coronary Artery Patients
Research Article
DOI:
https://doi.org/10.5281/zenodo.7749142Keywords:
Diabetic, Nondiabetic, Coronary Artery Disease, Cardiopulmonary Bypass, TroponinAbstract
Objective: The aim of this study is to compare the Troponin-I levels before and after CPB in diabetic and nondiabetic coronary artery patients.
Methods: The data of 20 diabetic and 20 nondiabetic patients who had undergone CPB-guided cardiac surgery for coronary artery disease were retrospectively included in the study. Diabetic patients were determined as group 1 and nondiabetic as group 2. The data of the two groups were compared and evaluated.
Results: The descriptive data of the study groups were similar and there was no statistically significant difference (p>0.05). There was a significant difference between preoperative and postoperative Troponin I levels of diabetic and nondiabetic patients (p<0.05).
Conclusion: In conclusion, preoperative and postoperative Troponin I levels increase after CPB in both diabetic and nondiabetic patients. However, this increase is higher in diabetic patients than in nondiabetic patients. We think that cardiac troponins may be predictors of the effect of CPB on the myocardium as well as the myocardial protection strategies (cardioplegia solutions, hypothermia, etc.) used during CPB.
References
McLaurin MD, Apple FS, Voss EM, Herzog CA, Sharkey SW. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chem. 1997;43(6 Pt 1):976-982.
Apucu G, Paksoy F, Dal MS, Hacıbekiroğlu İ, Sakacı T, Borlu F, ve ark. Diyabetik ve Nondiyabetik Kronik Böbrek Yetersizliği Hastalarında Hemodiyaliz Öncesi ve Sonrası Troponin-I Düzeylerinin Karşılaştırılması. Duzce Med J. 2012; 14(3): 11-14.
Amaç B, Koçarslan A, Aydın MS, Kankılıç N, Padak M, Dikme R. Kardiyopulmoner Bypass'ın Hemogram Parametreleri Üzerine Etkisi. Online Türk Sağlık Bilimleri Dergisi. 2021;6(1):102-111. doi:10.26453/otjhs.811833
Kağan As A, Engin M, Amaç B, et al. Del nido kardiyopleji kullanımının koroner baypas ameliyatları sonrası böbrek hasarı üzerine etkisi. Rev Doç Med Sütyen (1992) . 2021;67(9):1322-1327. doi:10.1590/1806-9282.20210642
Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017;18(6):331-344. doi:10.1038/nrg.2016.160
Rastgeldi K, Aydın MS, Amaç B, Abanoz M. Kardiyopulmoner Bypassın Sitokinler Üzerine Etkisi. J Cukurova Anesth Surg. 2022;5(3):413-20. doi: 10.36516/jocass.1160350
Alirezaei T, Jebreil Moosavi MJ, Irilouzadian R, Taziki E. Elevated Cardiac Troponin I following Asymptomatic Intradialytic Hypotension: A Pilot Study with a 2-Year Follow-Up. Int J Clin Pract. 2022;2022:4214429. Published 2022 Aug 1. doi:10.1155/2022/4214429
Chaulin A. Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hypertension. Vasc Health Risk Manag. 2021;17:431-443. Published 2021 Jul 31. doi:10.2147/VHRM.S315376
Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-16823. doi:10.1002/jcp.28350
Chaulin A. Cardiac Troponins: Contemporary Biological Data and New Methods of Determination. Vasc Health Risk Manag. 2021;17:299-316. Published 2021 Jun 3. doi:10.2147/VHRM.S300002
Chaulin A. Modern View on the Role of Sex-Specific Levels of High-Sensitive Cardiospecific Troponins T and I in the Diagnosis of Myocardial Infarction. Cardiol Res. 2023;14(1):22-31. doi:10.14740/cr1450
Nakai K, Nakai K, Nagane Y, et al. Serum levels of cardiac troponin I and other marker proteins in patients with chronic renal failure. Clin Exp Nephrol. 2004;8(1):43-47. doi:10.1007/s10157-003-0266-7
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Acta Medica Ruha
This work is licensed under a Creative Commons Attribution 4.0 International License.
