Is There a Relationship Between Helicobacter Pylori and Infantile Colic? Evaluation With Sociodemographic Variables
Research Article
DOI:
https://doi.org/10.5281/zenodo.18901515Anahtar Kelimeler:
Infantile Colic, Helicobacter Pylori, Risk Factors, Etiology, Incidence, TreatmentÖzet
Introduction: Infantile colic is a common condition in early infancy, characterised by episodes of inconsolable, high-pitched crying in otherwise healthy infants during the first three months of life. Despite its high prevalence and frequent healthcare utilisation, the etiology of infantile colic remains unclear, and no definitive risk factors have been established.
Objective: To investigate the association between Helicobacter pylori infection and infantile colic in infants aged 6 weeks to 3 months and to evaluate other potential risk factors.
Methods: This case–control study included 70 infants presenting to an outpatient clinic. Thirty-five infants diagnosed with infantile colic were compared with 35 age-matched healthy infants without colic. Helicobacter pylori positivity and additional potential risk factors were assessed and analysed between groups.
Results: Helicobacter pylori positivity was detected in 20% of infants with infantile colic and in 6.1% of infants in the control group. Although H. pylori infection was more frequently observed in the colic group, the difference did not reach statistical significance. No other evaluated risk factor showed a significant association with infantile colic.
Conclusion: While Helicobacter pylori infection was detected more frequently among infants with infantile colic, the findings do not support a significant etiological relationship. Larger, well-designed studies are needed to clarify the potential role of H. pylori in the pathogenesis of infantile colic.
Referanslar
Gatzinsky C, Sillen U, Thomberg S, Sjöström S. Bowel Habits in healthy infants and the prevalence of functional constipation, infant colic and infant dyschezia. Acta Paediatr, 2023 Jun; 112(6):1341-1350. DOI:10.1111/apd.16736
Hyman PE, Milla PJ, Benninga MA, Davidson GP, Fleisher DF, Taminiau J. Childhood functional gastrointestinal disorders: neo-nate/toddler. Gastroenterology 2006 Apr;130(5):1519-1526. DOI: 10.1053/j.gastro.2005.11.065
Fuller BF, Keefe MR, Curtin M. Acoustic analysis of cries from “normal” and “irritable” infants. West J Nurs Res 1994 Jun;16(3):243-251. DOI: 10.1177/019394599401600302
Gupta SK. Is colic a gastrointestinal disorder? Curr Opin Pediatr 2002;14:588–592. DOI: 10.1097/00008480-200210000-00005
Zamani M, Alizadeh-Tabari S, Hasanpour AH, Eusebi LH, Ford AC. Systemic review with meta-analysis: association of Helicobacter pylori infection with gastro-oesophageal reflux and its complications. Aliment Pharmacol Ther. 2021 Oct;54(8):988-998. DOI: 10.1111/apt.16585
. Kim JH, Lee SW, Kwon Y, Ha EK, An J, Cha HR, Jeong SJ, Han MY. Infantil Colic and the Subsequent Development of the Irritable Bowel Syndrome. J Neurogastroenterol Motil. 2022 Oct 30;28(4):618-629. DOI: 10.5056/jnm21181.
FitzGerald R, Smith SM. An Overview of Helicobacter pylori Infection. Methods Mol Biol. 2021;2283:1-14. DOI: 10.1007/978-1-0716-1302-3_1.
Huang YC, Wu MC, Leong PY. Helicobacter pylori and Immune-Mediated Diseases: A Complex Interplay. Int J Rheum Dis, 2025 Oct:28(10):e70443. DOI: 10.1111/1756-185x.70443
He J,Tan S,Lv J. Tripartite interplay: immune reconstitution dynamics in AIDS, gut microbiota, and Helicobacter pylori infection: current advances and therapeutic prospects. Gut Pathog. 2025 Jul 3;17(1):50. DOI: 10.1186/s13099-025-00726-z
Yang T, Zhang Y, Zhang H, Wu X, Sun J, Hua D, Pan K, Liu Q, Cui G, Chen Z. Intracellular presence and genetic relationship of Helicobacter pylori within neonates' fecal yeasts and their mothers' vaginal yeasts. 2023 Sep;40(9):401-413. DOI: 10.1002/yea.3891
Clifford TJ, Campbell MK, Speechley KN, Gorodzinsky F. Sequelae of infant colic. Arch Pediatr Adolesc Med 2002;156:1183–1187. DOI: 10.1001/archpedi.156.12.1183
Lehtonen L, Korventranta H. Infantile colic: seasonal incidence and crying profiles. Arch Pediatr Adolesc Med 1995;149:533–536. DOI: 10.1001/Archpedi.1995.02170180063009
Milidou I, Lindhard MS, Søndergaard C, Olsen J, Henriksen TB. Developmental Coordination Disorder in Children with a History of Infantile Colic. J Pediatr. 2015;167(3):725-730. DOI: 10.1016/j.jpeds201506005
Milidou I, Søndergaard C, Jensen MS, Olsen J, Henriksen TB. Gestational age, small for gestational age, and infantile colic. Paediatr Perinat Epidemiol. 2014;28(2):138-145. DOI: 10.1111/ppe.12095
van der Wal MF, van den Boom DC, Pauw-Plomp H, de Jonge GA. Mothers' reports of inf ant crying and soothing in a multicultural population. Arch Dis Child. 1998;79(4):312-317. DOI:10.1136/adc.79.4.312
Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):220-5. DOI:10.1097/01.all.0000225164.06016.5d.
Fazil M. Prevalence and risk factors for infantile colic in district mansehra. J Ayub Med Coll Abbottabad. 2011;23(2):115-117. PMID: 24800359
Rautava P, Helenius H, Lehtonen L, Psychosocial predisposing factors for infantile colic. BMJ. 19934;307(6904):600-604. DOI: 10.1136/bmj.3076904.600
Milidou I, Søndergaard C, Jensen MS, Olsen J, Henriksen TB. Gestational age, small for gestational age, and infantile colic. Paediatr Perinat Epidemiol. 2014 Mar;28(2):138-45. DOI: 10.1111/ppe.12095.
Søndergaard C, Skajaa E, Henriksen TB. Fetal growth and infantile colic. Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):444-447. DOI: 10.1136/fn.83.1.f44
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK. Probiotics to prevent infantile colic. Cochrane Database Syst Rev. 2019 Mar 13;3(3):CD012473. DOI: 10.1002/14651858.CD012473.pub2
Aktas S, Kucuk Alemdar D. Correlation between Infantile Colic and Maternal Breastfeeding Self-Efficacy, Breastfeeding Success and Breast Milk Amount. J Trop Pediatr. 2019 Aug 1;65(4):321-327. DOI: 10.1093/tropej/fmy054
Marzet CB, Burgos F, Compare MD, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacil-lus rhamnosus GG. 2022 Feb;120(1):e1-e7. DOI: 10.5546/aap.2022.eng.e1
Oggero R, Garbo G, Savino F, Mostert M. Dietary modifications versus dicyclomine hydrochloride in the treatment of severe infan-tile colic. Acta Paediatr 1994;83:222–225. DOI: 10.1111/j.1651-2227
Lucassen PLBJ, Assendelft WJJ, Gubbels JW, van Eijk JT, Dauwes AC. Infantile colic: crying time reduction with a whey hydroly-sate: a double-blind, randomized, placebo-controlled trial. Pediatrics 2000;106:1349–1354. DOI: 10.1542/peds.106.6.1349
Swadling C, Griffiths P. Is modified cow's milk formula effective in reducing symptoms of infant colic? Br J Community Nurs 2003 Jan;8(1):24-7. DOI: 10.12968/bjcn.2003.8.1.11019
Lucas A, St. James-Roberts I. Crying, fussing and colic behaviour in breast- and bottle-fed infants. Early Hum Dev 1998;53:9–18. DOI: 10.1016/s0378-3782(98)00032-2
Twomey JE, High P, Lester BM. Colic: What’s maternal mental health got to do with it? Infant Ment Health J. 2012 Sep;33(5):543-552. DOI: 10.1002/imhj.21344
Evans K, Evans R, Simmer K. Effect of the method of breast feeding on breast engorgement, mastitis, and infantile colic. Acta Paedi-atr 1995;84:849–852. DOI: 10.1111/j.1651-2227.1995.tb13777.x
Nurko S, Benninga MA, Solari S, Chumpitazi BP. Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interac-tion. Am J Gastroenterol. 2022 Jun 1;117(6):995-1009. DOI: 10.14309/ajg.0000000000001779
Crowcroft NS, Strachan DP. The social origins of infantile colic: questionnaire study covering 76747 infants. BMJ 1997; 314: 1325–1328. DOI: 10.1136/bmj.314.7090.1325
Radwan A, Shraim N, Abualhasan M, Salim L, Nazzal R, AbuAbaid Y. Maternal knowledge and practices regarding infantile colic in Palestine: a need for enhanced education and awareness. BMC Pregnancy Childbirth. 2025 Feb 28;25(1):223. DOI: 10.1186/s12884-025-07360-2.
Mai T, Fatheree NY, Gleason W, Liu Y, Rhoads JM. Infantile Colic: New Insights into an Old Problem. Gastroenterol Clin North Am. 2018 Dec;47(4):829-844. DOI: 10.1016/j.gtc.2018.07.008.
Garrison MM, Christakis DA. Infant colic. Pediatr Case Rev 2001 Oct;1(1):19-24. DOI: 10.1097/00132584-200110000-00003.
Mabeku LBK, Foguieng KNP, Mewa JEK, Ndombo POK. Rate of Helicobacter pylori acquisition in children and evidence of mother-child transmission in a Sub-Saharan setting. 2025 Dec;11(1):2482497. DOI: 10.1080/20565623.2025.2482497
Okuda M, Miyashiro E, Koike M, Okuda S, Minami M, Yoshikawa N. Breastfeeding prevents Helicobacter pylori infection in early childhood. Pediatr Int 2001; 43(6):714-715. DOI: 10.1046/j.1442-200x.2001.01481.x
Dore MP, Malay HM, Graham DY, Fanciulli G, Delitala G, Realdi G. Risk Factors Associated with Helicobacter pylori Infection in among Children in a Defined Geographic Area. Clin Infect Dis 2002;35(3):240-245. DOI: 10.1086/341415
Ali AS, Borei MB. Helicobacter pylori and Egyptian infantile colic. J Egypt Soc Parasitol. 2013;43(2):327-332. DOI:10.12816/0006389
Queiroz DM, Saito M, Rocha GA, Rocha AM, Melo FF, Checkley W, Braga LL, Silva IS, Gilman RH, Crabtree JE. Helicobacter pylori infection in infants and toddlers in South America: concordance between [13C]urea breath test and monoclonal H. pylori stool antigen test. J Clin Microbiol.2013;51(11):3735-3740. DOI: 10.1128/JCM.01752-13
Ali AM. Helicobacter pylori and Infantile Colic Arch Pediatr Adolesc Med. 2012;166 (7):648-650. DOI: 10.1001/archpediatrics.2011.1241
Duan M, Li Y, Liu J, Zhang W. Dong Y, Han Z. Wan M, Lin M, Lin B, Kong Q, Ding Y, Yang X, Zuo X, Li Y. Transmission routes and patterns of helicobacter pylori. 2023 Feb;28(1):e12945. DOI: 10.1111/hel.12945
Monajemzadeh M, Farahmand F, Vakilian F, Mahjoub F, Alam M, Kashef N. Breastfeeding and helicobacter pylori infektion in chil-dren with digestive symptom. Iran J Pediatr 2010; 20 (3): 330-334. PMID:23056725, PMCID:PMC3446053
Shah SC, Tarassishin L, Eisele C, Rendon A, Debebe A, Hawkins K, Hillenbrand C, Agrawal M, Torres J, Peek RM Jr, Stone J, Dubinsky M, Colombel JF, Peter I, Hu J. Breastfeeding Is Associated with Lower Likelihood of Helicobacter Pylori Colonization in Babies, Based on a Prospective USA Maternal-Infant Cohort. Dig Dis Sci. 2022 Nov;67(11):5149-5157. DOI: 10.1007/s10620-021-07371-x
Pan Y, Jiao FY. Helicobacter pylori infection and gastric microbiota: Insights into gastric and duodenal ulcer development. World J Gastroenterol. 2025 Feb 21;31(7): 100044. DOI: 10.3748/wjg.v31.i7.100044
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