Investigation of the Effect of Predialysis Patient Education on Covid-19 Disease Course and Renal Functions in Chronic Kidney Disease Patients with a History of Covid-19 Infection and Not Yet Receiving Renal Replacement Therapy

Research Article

Authors

DOI:

https://doi.org/10.5281/zenodo.8325381

Keywords:

COVID-19, SARS-CoV-2, Chronic kidney failure, Education of patients

Abstract

Objective: Investigation of the effect of predialysis patient education on the infection process and the course of renal functions in patients with chronic kidney failure (CKD) and Covid 19 infection.

Method: The cases followed in the Department of Nephrology were retrospectively scanned, and 98 patients with a diagnosis of CRF and a history of Covid-19 disease who did not receive renal replacement therapy were included. A comparison was made between the groups who received and did not receive training in terms of smoking, alcohol, drug use, additional disease characteristics, laboratory values, favipiravir use, hospitalization history, intubation rate, morbidity, mortality rate, and need for hemodialysis in the course.

Results: 34.7% of the cases were uneducated and 65.3% were educated. It was found that 38% of the uneducated cases and 62.5% of the educated cases were women. The rate of smoking was found to be higher in cases who did not receive education (p=0.008). It was found that the creatinine value of educated cases after Covid-19 decreased compared to the creatinine value before Covid-19 (p=0.004), and GFR median values increased significantly (p<0.001). It was found that educated cases had more favipiravir use (p=0.026).

Conclusion: In our study, it was shown that predialysis CKD patient education did not cause loss of renal function that may develop after Covid-19, and even improved kidney functions.

References

Mahase E. Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate. BMJ. (2020) 368:m641.

Guan W, Ni Z, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. (2020) 382:1708–20.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019. Novel coronavirus-infected pneumonia in Wuhan, China. JAMA. (2020) 323:1061–9.

Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The novel coronavirus 2019 epidemic and kidneys. Kidney Int. (2020) 97:824–8.

Basile C, Combe C, Pizzarelli F, Covic A, Davenport A, Kanbay M, et al. Recommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres. Nephrol Dial Transplant. (2020) 35:737–41.

Betjes MG. Immune cell dysfunction and inflammation in end-stage renal disease. Nat Rev Nephrol. (2013) 9:255–65.

Syed-Ahmed M, Narayanan M. Immune dysfunction and risk of infection in chronic kidney disease. Adv Chronic Kidney Dis. (2019) 26:8–15.

Naqvi SB, Collins AJ. Infectious complications in chronic kidney disease. Adv Chronic Kidney Dis. (2006) 13:199–204.

Dalrymple LS, Go AS. Epidemiology of acute infections among patients with chronic kidney disease. Clin J Am Soc Nephrol. (2008) 3:1487–93.

Thompson S, James M, Wiebe N, Hemmelgarn B, Manns B, Klarenbach S, et al. Cause of death in patients with reduced kidney function. J Am Soc Nephrol. (2015) 26:2504–11.

Devins GM, Mendelssohn DC, Barré PE, Binik YM. Predialysis psychoeducational intervention and coping styles influence time to dialysis in chronic kidney disease. Am J Kidney Dis. 2003 Oct;42(4):693-703.

Rognant N, Alamartine E, Aldigier JC, Combe C, Vendrely B, Deteix P, Cluzel P, Juillard L, Vrtovsnik F, Maurice C, Fave S, Laville M. Impact of prior CKD management in a renal care network on early outcomes in incident dialysis patients: a prospective observational study. BMC Nephrol. 2013 Feb 20;14:41.

Campbell KL, Ash S, Bauer JD. The impact of nutrition intervention on quality of life in pre-dialysis chronic kidney disease patients. Clin Nutr. 2008 Aug;27(4):537-44.

Bach KE, Kelly JT, Palmer SC, Khalesi S, Strippoli GFM, Campbell KL. Healthy Dietary Patterns and Incidence of CKD: A Meta-Analysis of Cohort Studies. Clin J Am Soc Nephrol. 2019 Oct 7;14(10):1441-1449.

Yan B, Su X, Xu B, Qiao X, Wang L. Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis. PLoS One. 2018 Nov 7;13(11):e0206134.

Navaneethan SD, Yehnert H, Moustarah F, Schreiber MJ, Schauer PR, Beddhu S. Weight loss interventions in chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol. 2009 Oct;4(10):1565-74.

Yu YJ, Wu IW, Huang CY, Hsu KH, Lee CC, Sun CY, Hsu HJ, Wu MS. Multidisciplinary predialysis education reduced the inpatient and total medical costs of the first 6 months of dialysis in incident hemodialysis patients. PLoS One. 2014 Nov 14;9(11):e112820.

Tay MZ, Poy CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nature Rew İmmuno 2020;20(6):363-74.

Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer. J Thorac Oncol. 2020 May;15(5):700-704.

Boccia M, Aronne L, Celia B, Mazzeo G, Ceparano M, D'Agnano V, Parrella R, Valente T, Bianco A, Perrotta F. COVID-19 and coagulative axis: review of emerging aspects in a novel disease. Monaldi Arch Chest Dis. 2020 May 19;90(2).

Dhont S, Derom E, Van Braeckel E, Depuydt P, Lambrecht BN. The pathophysiology of 'happy' hypoxemia in COVID-19. Respir Res. 2020 Jul 28;21(1):198.

Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang C. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020 Jul 1;5(7):802-810.

Cai Q, Huang D, Yu H, Zhu Z, Xia Z, Su Y, Li Z, Zhou G, Gou J, Qu J, Sun Y, Liu Y, He Q, Chen J, Liu L, Xu L. COVID-19: Abnormal liver function tests. J Hepatol. 2020 Sep;73(3):566-574.

Hossain MF, Hasana S, Mamun AA, Uddin MS, Wahed MII, Sarker S, Behl T, Ullah I, Begum Y, Bulbul IJ, Amran MS, Rahman MH, Bin-Jumah MN, Alkahtani S, Mousa SA, Aleya L, Abdel-Daim MM. COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management. Front Pharmacol. 2020 Oct 16;11:563478.

Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB, Nie X, Zhang C. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020 Jul;98(1):219-227.

Diao B, Wang C, Wang R, Feng Z, Zhang J, Yang H, Tan Y, Wang H, Wang C, Liu L, Liu Y, Liu Y, Wang G, Yuan Z, Hou X, Ren L, Wu Y, Chen Y. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nat Commun. 2021 May 4;12(1):2506.

Pan XW, Xu D, Zhang H, Zhou W, Wang LH, Cui XG. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020 Jun;46(6):1114-1116.

Devins GM, Mendelssohn DC, Barré PE, Binik YM. Predialysis psychoeducational intervention and coping styles influence time to dialysis in chronic kidney disease. Am J Kidney Dis. 2003 Oct;42(4):693-703.

Devins GM, Mendelssohn DC, Barré PE, Taub K, Binik YM. Predialysis psychoeducational intervention extends survival in CKD: a 20-year follow-up. Am J Kidney Dis. 2005 Dec;46(6):1088-98.

Shi Y, Xiong J, Chen Y, Deng J, Peng H, Zhao J, He J. The effectiveness of multidisciplinary care models for patients with chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol. 2018;50:301-312.

Imamura Y, Takahashi Y, Uchida S, Iwamoto M, Nakamura R, Yamauchi M, Ogawara Y, Goto M, Takeba K, Yaguchi N, Joki N. Effect of multidisciplinary care of dialysis initiation for outpatients with chronic kidney disease. Int Urol Nephrol. 2021 Feb 15.

Imamura Y, Takahashi Y, Hayashi T, Iwamoto M, Nakamura R, Goto M, Takeba K, Shinohara M, Kubo S, Joki N. Usefulness of multidisciplinary care to prevent worsening renal function in chronic kidney disease. Clin Exp Nephrol. 2019 Apr;23(4):484-492.

Toprak O. Effetiviness of multidisciplinary pre-dialysis education and team care on patients lifestyles and clinical outcomes. Nephrolog Dialysis Transplantation 28 (Supplement 1): i258–i270, 2013 50th European Renal Association-European Dialysis and Transplantation Association Congress, Istanbul-Türkiye, 18-21 May 2013

Toprak O, Kahve B, Oncu N, Koc F, Deniz H, Diri HB, Bugra T, Tezcan T. Impact of multidisciplinary predialysis education on the initial dialysis modality and vascular access routes. 39th EDTNA/ERCA International Conference, Dublin-Ireland, September 18-21, 2010

Toprak O, Kahve B, Tezcan T, Diri HB, Bugra T. The effect of multidisciplinary predialysis education on control of hypertension, smoking rate, salt intake, and the use of nephrotoxic drugs: a single center experience. XLVII ERA-EDTA Congress, Munich-Germany, June 25-28, 2010

Toprak O, Pamuk A, Ozdemir O, Bugra T, Diri HB, Tezcan T. The effect of multidisciplinary predialysis education on the incidence of emergency dialysis and emergency catheter placement: a single center experience. XLVII ERA-EDTA Congress, Munich-Germany, June 25-28, 2010.

Restrepo M. Health Status and the Role of Nutrition on SARS-CoV/Covid-19. Erişim Adresi: https:// nakedfoodmagazine.com/health-status-covid-19/ 2020

Mattioli AV, Ballerini Puviani M. Lifestyle at Time of COVID-19: How Could Quarantine Affect Cardiovascular Risk. American Journal of Lifestyle Medicine, 2020;14(3):240- 242.

Barazzoni R, Bischoff SC, Krznaric Z, Pirlich M, Singer P. Expert Statements and Practical Guidance for 154 dergipark.gov.tr/avrasyasbd Kartal, Ergin & Kanmış Nutritional Management of İndividuals With SARS-CoV-2 İnfection. Clinical Nutrition, 2020;4(20)301-400.

Anderson CA, Nguyen HA, Rifkin DE. Nutrition Interventions in Chronic Kidney Disease. Med Clin North Am. 2016;100:1265-1283.

Verkade MA, van de Wetering J, Klepper M, Vaessen LM, Weimar W, Betjes MG. Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients. Kidney Int. 2004;66:614–21.

Naidu, A.S., Pressman, P., ve Clemens, R.A. Coronavirus and Nutrition What Is the Evidence for Dietary Supplements Usage for COVID-19 Control and Management? Nutrition Today, 2021;56, 19-25.

Laviano A, Koverech A, Zanetti M. Nutrition support in the time of SARS-CoV-2 (COVID-19). Nutrition, 2020;74:1-2.

Beck MA. Selenium and vitamin E status: impact on Viral Pathogenicity. The Journal of Nutrition, 2007;137(5), 1338- 1340.

Ritz BW, Gardner EM. (2006). Malnutrition and energy restriction differentially affect viral immunity. The Journal of Nutrition, 136(5), 1141-1144.

Toprak O. Toprak’s Kidney Care: A New Comprehensive Kidney Care for Chronic Kidney Disease Patients and their Caregivers Am J Biomed Sci & Res. 2019 - 5(1).

Toprak O, Bozyel EA, Alp B, Kirik A. Discontinuation of Hemodialysis After 8 Years in Favor of Toprak’s Kidney Care in a Patient with End-Stage Kidney Disease, Am J Case Rep 2021; 22:e930857.

Wang S, Qin A, Pei G, Jiang Z, Dong L, Tan J, Tan L, Tang Y, Qin W. Cigarette smoking may accelerate the progression of IgA nephropathy. BMC Nephrol. 2021 Jun 29;22(1):239.

Bar Y, Barregard L, Sallsten G, Wallin M, Mölne J. Quantitative and semi-quantitative histopathological examination of renal biopsies in healthy individuals, and associations with kidney function. Apmis. 2016;124:393–400.

Hallan SI, Orth SR. Smoking is a risk factor in the progression to kidney failure. Kidney Int. 2011;80:516–523.

Leung J.M., Yang C.X., Tam A., Shaipanich T., Hackett T.L., Singhera G.K., Dorscheid D.R., Sin D.D. ACE-2 expression in the small airway epithelia of smokers and COPD patients: Implications for COVID-19. Eur. Respir. J. 2020;55:2000688

Guo F.R. Smoking links to the severity of Covid-19: An update of a meta-analysis. J. Med. Virol. 2020.

Hu L., Chen S., Fu Y., Gao Z., Long H., Wang J.M., Ren H.W., Zuo Y., Li H., Wang J., et al. Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Hospitalized Patients in Wuhan, China. Clin. Infect. Dis. 2020.

Wang M et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020;30:269–271.

Ghasemnejad-Berenji M, Pashapour S. Favipiravir and COVID-19: A Simplified Summary. Drug Res (Stuttg). 2021 Mar;71(3):166-170.

Manabe T, Kambayashi D, Akatsu H, Kudo K. Favipiravir for the treatment of patients with COVID-19: a systematic review and meta-analysis. BMC Infect Dis. 2021 May 27;21(1):489.

Appili Therapeutics Provides Update on Phase 3 PRESECO Clinical Trial Evaluating Avigan®/Reeqonus™ (Favipravir) November 12, 2021 07:19 AM Eastern Standard Time

Hsu CK, Lee CC, Chen YT, Ting MK, Sun CY, Chen CY, Hsu HJ, Chen YC, Wu IW. Multidisciplinary predialysis education reduces incidence of peritonitis and subsequent death in peritoneal dialysis patients: 5-year cohort study. PLoS One. 2018 Aug 23;13(8):e0202781.

Cho, E. J., Park, H. C., Yoon, H. B., Ju, K. D., Kim, H., Oh, Y. K., Yang, J., Hwang, Y. H., Ahn, C., & Oh, K. H. (2012). Effect of multidisciplinary pre-dialysis education in advanced chronic kidney disease: Propensity score matched cohort analysis. Nephrology, 17(5), 472-479.

Kunutsor SK, Laukkanen JA. Renal complications in COVID-19: a systematic review and meta-analysis. Ann Med. 2020 Nov;52(7):345-353.)

Lei CC, Lee PH, Hsu YC, Chang HY, Tung CW, Shih YH, Lin CL (2013) Educationalintervention in CKD retardsdiseaseprogressionandreducesmedicalcostsforpatientswithstage 5 CKD. Ren Fail 35(1):9–16.

Yu YJ, Wu W, Huang CY, Hsu KH, Lee CC, Sun CY, Hsu HJ, Wu MS (2014) Multidisciplinarypredialysiseducationreducedtheinpatientand total medicalcosts of thefrst 6 months of dialysis in incidenthemodialysispatients. PLoS ONE 9(11):e112820.

Chen PM, Lai TS, Chen PY, Lai CF, Yang SY, Wu V, Chiang CK, Kao TW, Huang JW, Chiang WC, Lin SL, Hung KY, Chen YM, Chu TS, Wu MS, Wu KD, Tsai TJ (2015) Multidisciplinarycare program foradvancedchronickidneydisease: reduces renal replacementandmedicalcosts. Am J Med 128(1):68–76.

Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020;11:995-8.

D. Selcen SALMANOĞLU et al., “COVID-19 Tanı Testleri, Tedavisindeki Aşılar ve İlaçlar; Güncel Durum,” Uludağ Üniversitesi Tıp Fakültesi Derg., vol. 47, no. 2, pp. 295–308, 2021.

Published

2023-09-20

How to Cite

Özkan, B., & Toprak, Ömer. (2023). Investigation of the Effect of Predialysis Patient Education on Covid-19 Disease Course and Renal Functions in Chronic Kidney Disease Patients with a History of Covid-19 Infection and Not Yet Receiving Renal Replacement Therapy: Research Article. Acta Medica Ruha, 1(3), 410–425. https://doi.org/10.5281/zenodo.8325381

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Research Articles