The Relationship Of Free ß-hCG, PAPP-A, AFP, ß-hCG, UE3 In Pregnancy With Fac, 50 Gram Glucose Screening Test And Birth Weight

Research Article




gestational diabetes mellitus, abnormal birth weight, pregnancy-associated plasma protein-A (PAPP-A), trimester, unconjugated estriol (uE3)


Objective: It is possible to improve the quality of health and care and to minimize high-cost medical expenses by closely monitoring the complications in infants born with abnormal fetal birth weights. Within the scope of this research, we aimed to elucidate the relationship between first and second-trimester screening tests plasma proteins and 50 g glucose tolerance test values used in gestational diabetes screening with estimated birth weight.

Method: A total of 831 cases with regular antenatal follow-ups in Ankara Atatürk Training and Research Hospital, Gynecology, and Obstetrics Clinic were enrolled. The first- trimester fetal aneuploidy screening determined PAPP-A and free-β-hCG values. The second- trimester triple test determined Alpha-feto protein, hCG, and unconjugated estriol values. Fasting blood glucose was measured at the first visit, and a 50 g oral glucose tolerance test (OGTT) was performed between 24 – 28 weeks of gestation. Pregnancies continued without complications and who gave birth at term (gestational age 37+0 weeks) were included in the study.

Results: When the relationship between the hormonal values used in the first and second-trimester aneuploidy screening and the 50 gr OGTT (mg/dl) values are examined, no correlation between free-beta-hCG and 50 g OGTT (mg/dl) (r= -0.055, p= 0.128). Maternal fasting blood glucose levels (r= -0.055, p= 0.131) did not reveal any relationship with first and second-trimester aneuploidy screening. PAPP-A (r= - 0.011, p= 0.765), AFP (r= -0.033, p= 0.369), uE3 (r= 0.035, p= 0.340). (Figure 14), and hCG values (r= -0.051, p= 0.164), also did not present correlation with maternal fasting blood glucose levels.

Conclusion: According to the results of our study, no relationship was found between the hormones used in the first trimester (PAPP-A and free-beta-hCG) and second-trimester (AFP, hCG, and uE3) aneuploidy screening and 50 g OGTT, maternal plasma blood glucose level and birth weight.


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How to Cite

Gezegen, S. (2023). The Relationship Of Free ß-hCG, PAPP-A, AFP, ß-hCG, UE3 In Pregnancy With Fac, 50 Gram Glucose Screening Test And Birth Weight: Research Article. Acta Medica Ruha, 1(3), 335–344.



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