Effect Of Ovulatıon Inductıon With Clomiphene Citrate On Ovarian Reserve Tests In Subfertıle Patıents
Research Article
DOI:
https://doi.org/10.5281/zenodo.10159636Keywords:
Ovarian Reserve Tests, Ovulation induction, Clomiphene Citrate, Insemination.Abstract
Objective: In this study, the variability of ovarian reserve (OR) tests such as basal FSH, estradiol, ultrasound-measured antral follicle count (AFC), and total ovarian volume (TOV) after ovulation induction with clomiphene citrate (CC) was investigated. We also aimed to elucidate the predictive value of ovarian reserve tests regarding pregnancy outcomes in patients who underwent ovulation induction with CC for intrauterine insemination (IUI).
Methods: This retrospective cohort study included 48 subfertile patients receiving IUI indications. Basal FSH and E2 levels, AFC and TOV were measured on the third day of the first cycle, in the second cycle when 50 mg/day of clomiphene citrate was started for ovulation induction, and in the third cycle in 23 patients out of 40 who could not get pregnant with IUI.
Results: OR tests between the cycles were compared with the paired t-test. In the statistical analysis, an increase in basal FSH, E2 , TOV, and TAF was observed after clomiphene citrate treatment, but this increase was not considered significant (p>0.05). There was no significant difference in OR tests between the group that become pregnant and the ones that did not have pregnancy after CC and IUI.
Conclusion: According to the data obtained, OR tests do not change in the cycle after the first CC and do not need to be repeated. We concluded that age, basal FSH and E2 values from OR tests, and TOV and TAF numbers from ultrasonographic parameters could not be used as prognostic factors in predicting pregnancies in pregnancies obtained with CC.
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